Acrylamide-Calcium Protease - Psoriasis Feb 13, 2009 9:10:13 GMT -7
Post by Rene on Feb 13, 2009 9:10:13 GMT -7
Acrylamide-Calcium Protease - Psoriasis
And type in "Acrylamide calcium protease psoriasis"
For more research into Calcium Protease try
By using a tissue plasminogen activator it is possible to analyse the difference in normal and pathological skin samples.
Tissue plasminogen activator (tPA) is a thrombolytic agent (clot-busting drug). It's approved for use in certain patients having a heart attack or stroke. The drug can dissolve blood clots, which cause most heart attacks and strokes.
tissue plasminogen activator, (TPA) (t-PA) t-plasminogen activator, [EC 22.214.171.124] a serine endopeptidase synthesized by endothelial cells, the major physiologic activator of plasminogen; when bound to fibrin clots it catalyzes the conversion of plasminogen to plasmin by hydrolysis of a specific arginine-valine bond.
Below is one example of the latest research done in this field.
Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples.
Kuwae K, Matsumoto-Miyai K, Yoshida S, Sadayama T, Yoshikawa K, Hosokawa K, Shiosaka S.
Department of Plastic Surgery, Osaka University Medical School, Osaka, Japan.
AIMS: The expression of human neuropsin (KLK8) mRNA in normal and pathological skin samples was analysed and the results compared with those for tissue plasminogen activator (tPA) mRNA. METHODS: Northern blot and in situ hybridisation analyses of KLK8 mRNA in normal and lesional skin of patients with cutaneous diseases were performed. RESULTS: A weak signal for KLK8 mRNA and no signal for tPA mRNA was seen in normal skin on northern blot analysis. Weak signals for KLK8 were localised to the superficial cells beneath the cornified layer in normal skin on in situ hybridisation. Psoriasis vulgaris (plague psoriasis), seborrheic keratosis, lichen planus, and squamous cell carcinoma skin samples, which show severe hyperkeratosis, displayed a high density of KLK8 mRNA on northern and in situ hybridisation analyses. The signals were localised in granular and spinous layers of lesional skin in all hyperkeratic samples, including the area surrounding the horn pearls of squamous cell carcinoma. To examine the relation between mRNA expression and terminal differentiation, the expression of KLK8 mRNA was analysed in cell cultures. When keratinisation proceeded in high calcium medium, a correlative increase in the expression of KLK8 mRNA was observed. CONCLUSION: The results are consistent with a role for this protease in the terminal differentiation of keratinocytes.
Plague Psoriasis should also be called Calcium Protease.
By using a tissue plasminogen activator it is possible to analyse the difference in normal and (psoriasis) pathological skin samples. The difference is a high calcium medium is found in pathological skin samples, in normal skin samples very little calcium is found in comparison.
This indeed makes sense as the most common sites of psoriasis especially plague psoriasis (the most common form of psoriasis) are of local trauma sites
This is also known as the "Koebner phenomenon"
Calcium is critical for many metabolic functions. While 99% of body calcium is found as part of the structure of bone and teeth, 1% found in plasma and body cells is crucial for such functions as nerve impulse conduction, and muscle contraction. Calcium plays a vital part in the regulation of cell growth.
The homeostasis of calcium is complex because the gastrointestinal tract, the bones, and the kidneys all affect calcium balance.
Calcium is the most abundant mineral in our body and where ever trauma is caused to the body calcium will play a role. Calcium is needed for blood clotting.
For some time it has been known that dietary factors which increase calcium absorption include certain amino acids, such as lysine and arginine, vitamin D, and lactose, soybeans, kale, spinach or other high oxalate-containing foods. Foods with high phosphate content, such as unpolished rice, hexaphosphoinositol in bran, or gluten decrease the intestinal absorptive efficiency for calcium. Other factors that decrease calcium absorption include the ingestion of alkali, increased gastrointestinal transit time, stress, immobilisation, thyroid hormone and cortisol or any of its synthetic analogs.